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  The resting brain: Unconstrained yet reliable

Shehzad, Z. E., Kelly, A. M. C., Reiss, P. T., Gee, D. G., Gotimer, K., Uddin, L. Q., et al. (2009). The resting brain: Unconstrained yet reliable. Cerebral Cortex, 19(10), 2209-2229. doi:10.1093/cercor/bhn256.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-E328-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5BBF-0
Genre: Journal Article

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Shehzad, Zarrar E., Author
Kelly, A. M. Clare, Author
Reiss, Philipp T., Author
Gee, Dylan G., Author
Gotimer, Kristin, Author
Uddin, Lucina Q., Author
Lee, Sang Han, Author
Margulies, Daniel S.1, Author              
Roy, Amy Krain, Author
Biswal, Bharat B., Author
Petkova, Eva, Author
Castellanos, F. Xavier, Author
Milham, Michael P., Author
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1External Organizations, ou_persistent22              

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 Abstract: Recent years have witnessed an upsurge in the usage of resting-state functional magnetic resonance imaging (fMRI) to examine functional connectivity (fcMRI), both in normal and pathological populations. Despite this increasing popularity, concerns about the psychologically unconstrained nature of the "resting-state" remain. Across studies, the patterns of functional connectivity detected are remarkably consistent. However, the test-retest reliability for measures of resting state fcMRI measures has not been determined. Here, we quantify the test-retest reliability, using resting scans from 26 participants at 3 different time points. Specifically, we assessed intersession (>5 months apart), intrasession (<1 h apart), and multiscan (across all 3 scans) reliability and consistency for both region-of-interest and voxel-wise analyses. For both approaches, we observed modest to high reliability across connections, dependent upon 3 predictive factors: 1) correlation significance (significantly nonzero > nonsignificant), 2) correlation valence (positive > negative), and 3) network membership (default mode > task positive network). Short- and long-term measures of the consistency of global connectivity patterns were highly robust. Finally, hierarchical clustering solutions were highly reproducible, both across participants and sessions. Our findings provide a solid foundation for continued examination of resting state fcMRI in typical and atypical populations.

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 Dates: 2009
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 458484
Other: P10585
DOI: 10.1093/cercor/bhn256
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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 19 (10) Sequence Number: - Start / End Page: 2209 - 2229 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440