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  Transient global ischemia specifically modulates visual P300 scalp distribution

Ullsperger, M., Mecklinger, A., Matthes-von Cramon, G., & von Cramon, D. Y. (2000). Transient global ischemia specifically modulates visual P300 scalp distribution. Clinical Neurophysiology, 111(12), 2245-2254. doi:10.1016/S1388-2457(00)00480-6.

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 Creators:
Ullsperger, Markus1, Author           
Mecklinger, Axel1, Author           
Matthes-von Cramon, Gabi1, Author           
von Cramon, D. Yves1, Author           
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

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Free keywords: Event-related potentials; P300; Anoxic encephalopathy; Transient global ischemia
 Abstract: OBJECTIVE: Latency, amplitude, and scalp topography of the visual P300 component was examined in patients who had suffered from transient global ischemia (TGI) due to cardiac arrest and in age matched clinical and healthy controls in order to investigate the diagnostic value of this component. METHOD: Event-related potentials (ERPs) were recorded from 19 scalp electrodes in a visual oddball paradigm. RESULTS: Mean latency of the P300 component was prolonged in both patient groups. Changes in scalp distribution of the P300, however, appear to be specific to anoxic-ischemic encephalopathy. In particular, a selective reduction of the P300 amplitudes at posterior recording sites was observed in TGI patients. Moreover, examination of the auditory P300 in TGI patients revealed that this selective change seems to be restricted to the visual modality. CONCLUSION: The results are discussed with respect to selective vulnerability of brain tissue to hypoxic-ischemic injury. After TGI a modality-specific subset of P300 generators, probably located in the transitional parieto-occipital and extrastriate occipital cortex, appears to be affected. It is also noted, that the visual P300 component could serve as an additional marker of TGI especially in patients who do not show neuropathological changes in structural brain images.

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Language(s): eng - English
 Dates: 2000
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 239500
ISI: 000165777900022
Other: P6943
DOI: 10.1016/S1388-2457(00)00480-6
 Degree: -

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Title: Clinical Neurophysiology
  Other : Clin. Neurophysiol.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 111 (12) Sequence Number: - Start / End Page: 2245 - 2254 Identifier: ISSN: 1388-2457
CoNE: https://pure.mpg.de/cone/journals/resource/954926941726