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  Transient signal changes in diffusion-weighted stimulated echoes during neuronal stimulation at 3T

Goerke, U., & Möller, H. E. (2007). Transient signal changes in diffusion-weighted stimulated echoes during neuronal stimulation at 3T. Journal of Magnetic Resonance Imaging, 25(5), 947-956. doi:10.1002/jmri.20891.

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資料種別: 学術論文

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 作成者:
Goerke, U., 著者
Möller, Harald E.1, 著者           
所属:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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キーワード: Apparent self-diffusion; fMRI; Stimulated echo; T 2; Transverse relaxation
 要旨: Purpose: To develop a sensitive method for detecting minute transient signal changes that can arise due to variations in the extravascular apparent self-diffusion coefficient, D, during neuronal activation. Materials and Methods: A three-pulse sequence that reads out a moderately diffusion-weighted (DW) primary echo (PRE) and a heavily DW stimulated echo (STE) was employed to investigate whether small transient signal changes in extravascular D occur in response to a visual stimulus. Contributions to signal changes caused by subtle differences in the transient variations of the apparent transverse relaxation constant, T2, between the PRE and STE were also quantified. Results: On z-maps obtained from the STE, more voxels showed significant stimulus-related signal changes compared to maps of the PRE. The average maximum signal change of the STE was larger than that of the PRE. The observed increase in the relative signal change was independent of the strength of the diffusion weighting. Conclusion: The STE is more sensitive to neuronal activity than the PRE. The discrepancy between the two echoes does not arise from transient changes in D, but from subtle differences in stimulus-related variations of T2 between the two echoes. © 2007 Wiley-Liss, Inc.

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言語: eng - English
 日付: 2006-02-272006-11-282007-04-042007-05
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子(DOI, ISBNなど): eDoc: 345796
その他: P8133
DOI: 10.1002/jmri.20891
PMID: 17410563
 学位: -

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Funding organization : Keck Foundation
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Funding organization : Mind Institute
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Grant ID : BTRR 008079
Funding program : -
Funding organization : National Institute of Health (NIH)

出版物 1

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出版物名: Journal of Magnetic Resonance Imaging
種別: 学術雑誌
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所属:
出版社, 出版地: [Hoboken, NJ] : Wiley
ページ: - 巻号: 25 (5) 通巻号: - 開始・終了ページ: 947 - 956 識別子(ISBN, ISSN, DOIなど): ISSN: 1053-1807