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Free keywords:
conformation analysis • hydrogen transfer • IR-UV spectroscopy • neutral zwitterions • peptide design
Abstract:
No solution for the zwitterion: An acid- and base-containing pentapeptide was designed to explore the possibility of zwitterion formation in the gas phase, in the absence of a net charge. Internal proton transfer between peptide side chains in vacuo gave a zwitterion (highlighted in yellow; the canonical form is highlighted in blue), which was identified by gas-phase IR spectroscopy.
