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Free keywords:
cellular biophysics; signal processing; statistical analysis; genetics; optimisation
Abstract:
A simple flow network model of biological signal transduction is investigated. Networks with prescribed signal processing functions, robust against random node or link removals, are designed through an evolutionary optimization process. Statistical properties of large ensembles of such networks, including their characteristic motif distributions, are determined. Our analysis suggests that robustness against link removals plays the principal role in the architecture of real signal transduction networks and developmental genetic transcription networks.
