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  Interaction between the bio-surfactant Surfactin and lipid membranes - COLL 310

Holzwarth, J. F., Kell, H., Couderc-Azouani, S., Vater, J., Dietrich, U., Heenan, R., et al. (2004). Interaction between the bio-surfactant Surfactin and lipid membranes - COLL 310. Abstracts of Papers of the American Chemical Society, 227, U853-U853.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0011-0E05-9 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0011-0E06-7
Genre: Conference Paper

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 Creators:
Holzwarth, Josef F.1, Author           
Kell, Henny1, Author           
Couderc-Azouani, Sabine1, Author           
Vater, Joachim, Author
Dietrich, Undine, Author
Heenan, Richard, Author
Gutberlet, Thomas, Author
Penfold, Jeffery, Author
Boettcher, Christoph, Author
Affiliations:
1Physical Chemistry, Fritz Haber Institute, Max Planck Society, ou_634546              

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 Abstract: The bio-surfactant Surfactin possesses antifungal, antiviral and antitumural properties. We investigated the interaction of Surfactin with lipid monolayers and vesicles applying differential scanning calorimetry (DSC), static light scattering, cryo-transmission electron microscopy (TEM) fluorescence microscopy and small angle neutron scattering (SANS). Our target was to clarify how lipid membranes are influenced by the insertion of different amounts of Surfactin: This should lead to a better understanding of the biological function of Surfactin. Low concentrations of Surfactin were solubilized in monolayers or vesibles of L-a-Di-myristoylphosphatidylcholine (DMPC) or L-a-Dipalmitoylphosphatidylcholine (DPPC) and normal phase transition behavior was observed. In the range from 4–20 % of Surfactin to lipid increasing heysteresis was characteristic for the phase behavior. At higher concentrations of Surfactin the vesicles disintegrated into mixed micelles. In addition to the thermodynamic and structural investigations we also performed temperature-jump experiments to learn about the dynamics of the lipid-Surfactin system.

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Language(s): eng - English
 Dates: 2004
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 208314
URI: http://oasys2.confex.com/acs/227nm/techprogram/P713157.HTM
 Degree: -

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Title: 227th ACS National Meeting – Division of Colloid and Surface Chemistry. Symposium in Memory of Arthur W. Adamson
Place of Event: Anaheim, CA
Start-/End Date: 2004-03-28 - 2004-04-01

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Title: Abstracts of Papers of the American Chemical Society
Source Genre: Journal
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Publ. Info: American Chemical Society
Pages: - Volume / Issue: 227 Sequence Number: - Start / End Page: U853 - U853 Identifier: ISBN: 0-8412-3925-8
ISSN: 0065-7727