English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Peptide hormones regulating appetite: Focus on neuroimaging studies in humans

Schlögl, H., Percik, R., Horstmann, A., Villringer, A., & Stumvoll, M. (2011). Peptide hormones regulating appetite: Focus on neuroimaging studies in humans. Diabetes/Metabolism Research and Reviews, 27(2), 104-112. doi:10.1002/dmrr.1154.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0011-28BE-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-7012-F
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Schlögl, Haiko1, Author              
Percik, Ruth1, 2, Author
Horstmann, Annette3, Author              
Villringer, Arno3, 4, Author              
Stumvoll, Michael1, Author
Affiliations:
1Faculty of Medicine, University of Leipzig, Germany, ou_persistent22              
2Institute of Endocrinology, Sheba Medical Center, Tel-Aviv, Israel, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

Content

show
hide
Free keywords: Gut peptides; Neuroimaging; Obesity; Appetite; Regulation of eating behaviour
 Abstract: In recent years, knowledge about hormonal feedback from the gastrointestinal tract and adipose tissue has increased tremendously. Peptide hormones modulating hunger have been intensively studied, mostly in animals but increasingly also in humans. The first therapeutic agents, such as GLP-1 analogues, are in successful clinical use for T2D and may beneficially affect hunger and reduce weight. Data from in vitro studies and animals provide detailed insight into regulatory mechanisms leading to peptide secretion and receptor bindings, as well as to the distribution of receptors involved in different parts of the body. With neuroimaging techniques human brain structures have been identified that play a role in hunger, satiety and eating behaviour. These include the primary gustatory (insular) and olfactory (pyriform) cortex and regions with a highly permeable blood-brain barrier (hypothalamus, brain stem), which facilitates humoral input via gut peptides and leptin. In addition, cerebral networks involved in higher cognitive functions, especially those relevant to reward, pleasure and also addiction (ventral and dorsal striatum, amygdala, orbitofrontal cortex (OFC), prefrontal cortex (PFC)) were shown to be involved. First indications of direct influences of peptide hormones on these networks have become available from neuroimaging studies administrating synthetic PYY, ghrelin and leptin. Insulin also appears to play an important role as a central satiety hormone, and evidence indicating the possibility of central insulin resistance in obesity is available.

Details

show
hide
Language(s): eng - English
 Dates: 2011-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 538220
Other: P11783
DOI: 10.1002/dmrr.1154
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Diabetes/Metabolism Research and Reviews
  Other : Diabetes, Metabolism Research and ReviewsABBREVIATION
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford, UK : Wiley-Blackwell
Pages: - Volume / Issue: 27 (2) Sequence Number: - Start / End Page: 104 - 112 Identifier: ISSN: 1520-7552
CoNE: https://pure.mpg.de/cone/journals/resource/1520-7552