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  Blocking central opiate function modulates hedonic impact and anterior cingulate response to rewards and losses

Petrovic, P., Pleger, B., Seymour, B., Klöppel, S., De Martino, B., Critchley, H. D., et al. (2008). Blocking central opiate function modulates hedonic impact and anterior cingulate response to rewards and losses. The Journal of Neuroscience, 28(42), 10509-10516.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0011-2BBA-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5BE1-F
Genre: Journal Article

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 Creators:
Petrovic, Predrag, Author
Pleger, Burkhard1, Author              
Seymour, Ben, Author
Klöppel, Stefan, Author
De Martino, Benedetto, Author
Critchley, Hugo D., Author
Dolan, Raymond J., Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Naloxone; Opioid; Reward; fMRI; cingulate; Insula; Human
 Abstract: Reward processing is linked to specific neuromodulatory systems with a dopaminergic contribution to reward learning and motivational drive being well established. Neuromodulatory influences on hedonic responses to actual receipt of reward, or punishment, referred to as experienced utility are less well characterized, although a link to the endogenous opioid system is suggested. Here, in a combined functional magnetic resonance imaging–psychopharmacological investigation, we used naloxone to block central opioid function while subjects performed a gambling task associated with rewards and losses of different magnitudes, in which the mean expected value was always zero. A graded influence of naloxone on reward outcome was evident in an attenuation of pleasure ratings for larger reward outcomes, an effect mirrored in attenuation of brain activity to increasing reward magnitude in rostral anterior cingulate cortex. A more striking effect was seen for losses such that under naloxone all levels of negative outcome were rated as more unpleasant. This hedonic effect was associated with enhanced activity in anterior insula and caudal anterior cingulate cortex, areas implicated in aversive processing. Our data indicate that a central opioid system contributes to both reward and loss processing in humans and directly modulates the hedonic experience of outcomes.

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 Dates: 2008
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 546820
Other: P10227
CoNE: https://pure.mpg.de/cone1523/JNEUROSCI.2807-08.2008
 Degree: -

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Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 28 (42) Sequence Number: - Start / End Page: 10509 - 10516 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1