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  Neurons and the synaptic basis of the fMRI signal associated with cognitive flexibility

Stemme, A., Deco, G., Busch, A., & Schneider, W. X. (2005). Neurons and the synaptic basis of the fMRI signal associated with cognitive flexibility. NeuroImage, 26(2), 454-470. doi:10.1016/j.neuroimage.2005.01.044.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0011-2C2A-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-8624-4
Genre: Journal Article

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 Creators:
Stemme, Anja1, Author
Deco, Gustavo1, Author
Busch, Astrid1, Author
Schneider, Werner X.2, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Event-related fMRI; Cognitive set-shifting; Wisconsin Card Sorting Test; Attention; Working memory; PFC
 Abstract: The Wisconsin Card Sorting Test (WCST) is well known to test cognitive flexibility in terms of set-shifting capabilities. Many fMRI studies with behaving monkeys as well as human subjects have shown transient neural activity in the Prefrontal Cortex (PFC), as indicated by an increase in the fMRI signal, following a rule change in the WCST or when using a WCST-like paradigm. We present a computational model, covering a limited number of PFC neurons and using precise biophysical descriptions, which is able to simulate WCS-like tests. Further, the detailed neuronal representation of the model allows us to calculate the resulting fMRI signal. Thus, we are able to analyze the adequacy of the model and its structure by comparing the calculated fMRI signal with the experimental data which in turn provides promising insights into the neural base of the increase in the fMRI signal.

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 Dates: 2005
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 546850
Other: P6252
DOI: 10.1016/j.neuroimage.2005.01.044
 Degree: -

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Title: NeuroImage
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 26 (2) Sequence Number: - Start / End Page: 454 - 470 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166