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  Positional brain deformation visualized with magnetic resonance morphometry

Schnaudigel, S., Preul, C., Ugur, T., Mentzel, H. J., Witte, O. W., Tittgemeyer, M., et al. (2010). Positional brain deformation visualized with magnetic resonance morphometry. Neurosurgery, 66(2), 376-384. doi:10.1227/01.NEU.0000363704.74450.B4.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0011-2D70-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-F9A5-2
Genre: Journal Article

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Schnaudigel, Sonja1, 2, Author
Preul, Christoph1, Author
Ugur, Tarik3, Author
Mentzel, Hans Joachim4, Author
Witte, Otto W.1, Author
Tittgemeyer, Marc5, Author              
Hagemann, Georg1, Author
Affiliations:
1Department of Neurology, Friedrich-Schiller-University, Jena, Germany, ou_persistent22              
2Department of Neurology, Georg-August-University, Goettingen, Germany, ou_persistent22              
3Department of Psychiatry and Psychotherapy, Rheinische Kliniken, Essen, Germany, ou_persistent22              
4Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller-University, Jena, Germany, ou_persistent22              
5Department Cognitive Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634563              

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 Abstract: OBJECTIVE: To assess and visualize gravitational effects on brain morphology and the position of the brain within the skull by magnetic resonance (MR) morphometry in order to identify confounding effects and possible sources of error for accurate planning of neurosurgical interventions. METHODS: Three-dimensional MR imaging data sets of 13 healthy adults were acquired in different positions in the scanner. With a morphometric approach, data sets were evaluated by deformation field analysis and the brain boundary shift integral. Distortions of the brain were assessed comparing right versus left and prone versus supine positioning, respectively. RESULTS: Two effects could be differentiated: 1) greatest brain deformation of up to 1.7 mm predominantly located around central brain structures in the lateral direction and a less pronounced change after position changes in posterior-anterior direction, and 2) the brain boundary shift integral depicted position-dependent brain shift relative to the inner skull. CONCLUSION: Position-dependent effects on brain structure may undermine the accuracy of neuronavigational and other neurosurgical procedures. Furthermore, in longitudinal MR volumetric studies, gravitational effects should be kept in mind and the scanning position should be rigidly controlled for.

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 Dates: 2010-02
 Publication Status: Published in print
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Title: Neurosurgery
Source Genre: Journal
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Publ. Info: Baltimore, MD : Lippincott, Williams & Wilkins
Pages: - Volume / Issue: 66 (2) Sequence Number: - Start / End Page: 376 - 384 Identifier: ISSN: 0148-396X
CoNE: https://pure.mpg.de/cone/journals/resource/954925475458