English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Optical bedside monitoring of cerebral perfusion: Technological and methodological advances applied in a study on acute ischemic stroke

Steinkellner, O., Gruber, C., Wabnitz, H., Jelzow, A., Steinbrink, J., Fiebach, J. B., et al. (2010). Optical bedside monitoring of cerebral perfusion: Technological and methodological advances applied in a study on acute ischemic stroke. Journal of Biomedical Optics, 15(6): 061708. doi:10.1117/1.3505009.

Item is

Files

show Files

Locators

show
hide
Locator:
https://doi.org/10.1117/1.3505009 (Publisher version)
Description:
-
OA-Status:
Green

Creators

show
hide
 Creators:
Steinkellner, Oliver1, Author
Gruber, Clemens2, Author
Wabnitz, Heidrun1, Author
Jelzow, Alexander1, Author
Steinbrink, Jens3, Author
Fiebach, Jochen B.3, Author
Macdonald, Rainer1, Author
Obrig, Hellmuth2, 4, 5, Author           
Affiliations:
1Physikalisch-Technische Bundesanstalt, Berlin, Germany, ou_persistent22              
2Charité Universitätsmedizin Berlin, Neurologische Klinik, Berlin, Germany, ou_persistent22              
3Charité Universitätsmedizin Berlin, Center for Stroke Research Berlin, Germany, ou_persistent22              
4Universitätsklinik Leipzig Klinik für Kognitive Neurologie, Leipzig, Germany, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

Content

show
hide
Free keywords: bolus tracking; cerebral perfusion; indocyanine green; near-infrared spectroscopy; optical imaging; time-domain measurements
 Abstract: We present results of a clinical study on bedside perfusion monitoring of the human brain by optical bolus tracking. We measure the kinetics of the contrast agent indocyanine green using time-domain near-IR spectroscopy (tdNIRS) in 10 patients suffering from acute unilateral ischemic stroke. In all patients, a delay of the bolus over the affected when compared to the unaffected hemisphere is found (mean: 1.5 s, range: 0.2 s to 5.2 s). A portable time-domain near-IR reflectometer is optimized and approved for clinical studies. Data analysis based on statistical moments of time-of-flight distributions of diffusely reflected photons enables high sensitivity to intracerebral changes in bolus kinetics. Since the second centralized moment, variance, is preferentially sensitive to deep absorption changes, it provides a suitable representation of the cerebral signals relevant for perfusion monitoring in stroke. We show that variance-based bolus tracking is also less susceptible to motion artifacts, which often occur in severely affected patients. We present data that clearly manifest the applicability of the tdNIRS approach to assess cerebral perfusion in acute stroke patients at the bedside. This may be of high relevance to its introduction as a monitoring tool on stroke units. © 2010 Society of Photo-Optical Instrumentation Engineers.

Details

show
hide
Language(s): eng - English
 Dates: 2010-09-012010-11-192010
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000287171100015
DOI: 10.1117/1.3505009
PMID: 21198156
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : Hypo- and Hyperfusion during subacute Stroke. Tracking Perfusion Dynamics in stroke Patients with Optical Imaging
Grant ID : 01GZ0710/01GZ0711
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : 01EO0801
Funding program : -
Funding organization : Center for Stroke Research Berlin
Project name : -
Grant ID : FP7-HEALTH-2008-201076
Funding program : Seventh Framework Programme (FP7/2007-2013)
Funding organization : European Commission (EC)

Source 1

show
hide
Title: Journal of Biomedical Optics
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Bellingham, WA : Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society
Pages: - Volume / Issue: 15 (6) Sequence Number: 061708 Start / End Page: - Identifier: ISSN: 1083-3668
CoNE: https://pure.mpg.de/cone/journals/resource/954925607859