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  Dynamic causal modeling of subcortical connectivity of language

David, O., Maess, B., Eckstein, K., & Friederici, A. D. (2011). Dynamic causal modeling of subcortical connectivity of language. The Journal of Neuroscience, 31(7), 2712-2717. doi:10.1523/JNEUROSCI.3433-10.2011.

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https://doi.org/10.1523/JNEUROSCI.3433-10.2011 (Publisher version)
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 Creators:
David, Olivier1, Author
Maess, Burkhard2, Author                 
Eckstein, Korinna3, Author           
Friederici, Angela D.3, Author           
Affiliations:
1Grenoble Institut des Neuroscience, INSERM U 836, 38042 Grenoble, France, ou_persistent22              
2Methods and Development Unit MEG and EEG: Signal Analysis and Modelling, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Acoustic Stimulation; Adult; Bayes Theorem; Brain; Brain Mapping; Comprehension; Electroencephalography; Evoked Potentials; Female; Functional Laterality; Humans; Language; Magnetic Resonance Imaging; Magnetoencephalography; Male; Monte Carlo Method; Neural Pathways; Nonlinear Dynamics; Young Adult
 Abstract: Subcortical-cortical interactions in the language network were investigated using dynamic causal modeling of magnetoencephalographic data recorded during auditory comprehension. Participants heard sentences that either were correct or contained violations. Sentences containing violations had syntactic or prosodic violations or both.Weshow that a hidden source, modeling magnetically silent deep nuclei, is required to explain the data best. This is in line with recent brain imaging studies and intracranial recordings suggesting an involvement of subcortical structures in language processing. Here, the processing of syntactic and prosodic violations elicited a global increase in the amplitude of evoked responses, both at the cortical and subcortical levels. As estimated by Bayesian model averaging, this was accompanied by various changes in cortical-cortical and subcortical- cortical connectivity. The most consistent findings in relation to violations were a decrease of reentrant inputs to Heschl's gyrus (HG) and of transcallosal lateral connections. These results suggest that in conditions where one hemisphere detects a violation, possibly via fast thalamocortical (HG) loops, the intercallosal connectivity is reduced to allow independent processing of syntax (left hemisphere) and of prosody (right hemisphere). This study is the first demonstration in cognitive neuroscience that subcortical- cortical loops can be empirically investigated using noninvasive electrophysiological recordings. Copyright © 2011 the authors.

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Language(s): eng - English
 Dates: 2011-02-16
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1523/JNEUROSCI.3433-10.2011
PMID: 21325540
PMC: PMC3384564
 Degree: -

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Project name : -
Grant ID : ANR-09-EMER-006
Funding program : -
Funding organization : Agence Nationale pour la Recherche (ANR)

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Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 31 (7) Sequence Number: - Start / End Page: 2712 - 2717 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187