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  Predictors of adherence to antiretroviral treatment and therapeutic success among children in South Africa

Müller, A. D., Bode, S., Myer, L., Stahl, J., & von Steinbüchel, N. (2011). Predictors of adherence to antiretroviral treatment and therapeutic success among children in South Africa. Aids Care, 23(2), 129-138. doi:10.1080/09540121003758523.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0011-52FA-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-FFAA-8
Genre: Journal Article

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 Creators:
Müller, Alexandra D.1, Author
Bode, Stefan2, Author              
Myer, Landon3, 4, Author
Stahl, Jutta5, Author
von Steinbüchel, Nicole1, Author
Affiliations:
1Department of Medical Psychology and Medical Sociology, Georg August University, Göttingen, germany, ou_persistent22              
2Max Planck Fellow Research Group Attention and Awareness, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634553              
3Centre for Infections Diseases Epidemiology & Research, School of Public Health and Family Medicine, University of Cape Town, South Africa, ou_persistent22              
4International Centre for Aids Care and Treatment Programs Department of Epidemiology, Mailman School of Public Health, Columbia University in the City of New York, NY, USA, ou_persistent22              
5Department of Psychology, University of Cologne, Germany, ou_persistent22              

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Free keywords: HIV; Pediatric; Adherence; Social determinants of health; Resource-limited setting
 Abstract: The recent years have shown an up-scaling of treatment programs for HIV-infected children in resource-limited settings, with an increased focus on adherence. Little is known, however, about the influence of socioeconomic as well as caregivers' health beliefs on both adherence and virologic outcome of pediatric antiretroviral treatment in these settings. We conducted a cross-sectional study with 57 caregiver–child dyads at a public hospital in Cape Town, South Africa. Adherence was electronically monitored over three months, viral loads were available pre- and post-study. Caregivers answered questionnaires on their socioeconomic situation, attitudes toward and knowledge about treatment, and quality of life. Young children with a mean age of 51 months (SD 25.6) were investigated, and all were cared for by female caregivers. Mean adherence was 81%, and 67% of children achieved virologic suppression (VS). Household income, educational status, and child characteristics were not significantly correlated with adherence. Disclosure of both the child's and the caregiver's HIV status was linked to achieving VS and was a significant predictor for VS. A model including child's health status, caregiver's language skills, caregiver's disclosure, and perceived stigmatization could explain 95% of the variance in VS.

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Language(s): eng - English
 Dates: 2010-07-192011
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 562468
Other: P11421
DOI: 10.1080/09540121003758523
 Degree: -

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Title: Aids Care
Source Genre: Journal
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Affiliations:
Publ. Info: Abingdon, Oxfordshire, U.K. : Carfax Pub. Co.
Pages: - Volume / Issue: 23 (2) Sequence Number: - Start / End Page: 129 - 138 Identifier: ISSN: 0954-0121
CoNE: https://pure.mpg.de/cone/journals/resource/954925272406