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  Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina

Hoon, M., Soykan, T., Falkenburger, B., Hammer, M., Patrizi, A., Schmidt, K. F., et al. (2011). Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina. Proceedings of the National Academy of Sciences of the United States of America, 108(7), 3053-3058. doi:10.1073/pnas.1006946108.

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Hoon, M., Autor
Soykan, T., Autor
Falkenburger, B., Autor
Hammer, M., Autor
Patrizi, A., Autor
Schmidt, K. F., Autor
Sassoe-Pognetto, M., Autor
Loewel, S., Autor
Moser, T., Autor
Taschenberger, Holger1, Autor                 
Brose, N., Autor
Varoqueaux, F., Autor
Affiliations:
1Research Group of Activity-Dependent and Developmental Plasticity at the Calyx of Held, MPI for Biophysical Chemistry, Max Planck Society, ou_578581              

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 Zusammenfassung: Neuroligins (NL1–NL4) are postsynaptic adhesion proteins that control the maturation and function of synapses in the central nervous system (CNS). Loss-of-function mutations in NL4 are linked to rare forms of monogenic heritable autism, but its localization and function are unknown. Using the retina as a model system, we show that NL4 is preferentially localized to glycinergic postsynapses and that the loss of NL4 is accompanied by a reduced number of glycine receptors mediating fast glycinergic transmission. Accordingly, NL4-deficient ganglion cells exhibit slower glycinergic miniature postsynaptic currents and subtle alterations in their stimulus-coding efficacy, and inhibition within the NL4-deficient retinal network is altered as assessed by electroretinogram recordings. These data indicate that NL4 shapes network activity and information processing in the retina by modulating glycinergic inhibition. Importantly, NL4 is also targeted to inhibitory synapses in other areas of the CNS, such as the thalamus, colliculi, brainstem, and spinal cord, and forms complexes with the inhibitory postsynapse proteins gephyrin and collybistin in vivo, indicating that NL4 is an important component of glycinergic postsynapses.

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Sprache(n): eng - English
 Datum: 2011-02-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1073/pnas.1006946108
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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : PNAS
  Andere : Proceedings of the National Academy of Sciences of the USA
  Kurztitel : Proc. Natl. Acad. Sci. U. S. A.
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 108 (7) Artikelnummer: - Start- / Endseite: 3053 - 3058 Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230