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  Declarative memory consolidation in humans: A prospective functional magnetic resonance imaging study

Takashima, A., Petersson, K. M., Rutters, F., Tendolkar, I., Jensen, O., Zwarts, M. J., et al. (2006). Declarative memory consolidation in humans: A prospective functional magnetic resonance imaging study. Proceedings of the National Academy of Sciences of the United States of America [PNAS], 103(3), 756-761.

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PNAS-2006-Takashima-756-61.pdf (Publisher version), 361KB
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PNAS-2006-Takashima-756-61.pdf
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 Creators:
Takashima, Atsuko1, Author           
Petersson, Karl Magnus1, Author           
Rutters, F. 1, Author
Tendolkar, I. 1, 2, Author
Jensen, O.1, Author
Zwarts, M. J. 3, Author
McNaughton, B. L.4, Author
Fernández, G. 1, 5, Author
Affiliations:
1F. C. Donders Center, Radboud University Nijmegen, ou_persistent22              
2Department of Psychiatry, Radboud University, Nijmegen, The Netherlands, ou_persistent22              
3Department of Clinical Neurophysiology, Radboud University, Nijmegen, The Netherlands, ou_persistent22              
4Division of Neural Systems, University of Arizona,Tucson, USA, ou_persistent22              
5Neurology, Radboud University Nijmegen, Netherlands, ou_persistent22              

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Free keywords: hippocampus; retrograde amnesia; sleep; ventral medial prefrontal cortex; recognition
 Abstract: Retrieval of recently acquired declarative memories depends on
the hippocampus, but with time, retrieval is increasingly sustainable
by neocortical representations alone. This process has been
conceptualized as system-level consolidation. Using functional
magnetic resonance imaging, we assessed over the course of three
months how consolidation affects the neural correlates of memory
retrieval. The duration of slow-wave sleep during a nap/rest
period after the initial study session and before the first scan
session on day 1 correlated positively with recognition memory
performance for items studied before the nap and negatively with
hippocampal activity associated with correct confident recognition.
Over the course of the entire study, hippocampal activity for
correct confident recognition continued to decrease, whereas activity
in a ventral medial prefrontal region increased. These findings,
together with data obtained in rodents, may prompt a
revision of classical consolidation theory, incorporating a transfer
of putative linking nodes from hippocampal to prelimbic prefrontal
areas.

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Language(s): eng - English
 Dates: 2006
 Publication Status: Issued
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 Rev. Type: Peer
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Title: Proceedings of the National Academy of Sciences of the United States of America [PNAS]
Source Genre: Journal
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Pages: - Volume / Issue: 103 (3) Sequence Number: - Start / End Page: 756 - 761 Identifier: DOI: 10-1073/pnas.0507774103