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  Bicoid - morphogen function revisited.

Löhr, U., Chun, H. R., Beller, M., & Jäckle, H. (2010). Bicoid - morphogen function revisited. Fly, 4(3), 236-240. doi:10.4161/fly.4.3.11862.

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Löhr, U.1, Author           
Chun, H. R., Author
Beller, M.1, Author           
Jäckle, H.1, Author           
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1Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578590              

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 Abstract: Bicoid (Bcd) functions as a morphogen during Drosophila development. Accordingly, bcd mRNA is maternally localized to the anterior pole of the embryo, and Bcd forms an anterior/posterior gradient, which functions in a concentration dependent fashion. Thus, nuclei receiving identical amounts of Bcd should express the same target genes. However, we found that ectopic, uniform expression of Bcd causes anterior gene expression in the posterior with mirror image polarity, indicating that one or several additional factors must provide positional information. Recently, we have shown that one of these factors is Capicua (Cic), a ubiquitous maternal repressor that is down-regulated at the embryonic termini by maternal Torso, a key component of the maternal terminal system. Cic acts on Bcd dependent enhancer elements by repression and thereby controls the posterior limit of Bcd target gene expression. Based on these new findings, we propose that spatial control of gene expression in the anterior region of the embryo is not solely the result of Bcd morphogen action. Rather, it relies on a "morphogenic network" that integrates the terminal system and Bcd activities, providing both polarity and spatial information to the prospective head region of the developing embryo.

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Language(s): eng - English
 Dates: 2010-08-012010
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.4161/fly.4.3.11862
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Title: Fly
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Pages: - Volume / Issue: 4 (3) Sequence Number: - Start / End Page: 236 - 240 Identifier: -