Generation and characterization of an Advillin-Cre driver mouse line

Zurborg, Sandra; Piszczek, Agnieszka; Martinez, Conception; Hublitz, Philip; Al Banchaabouchi, Mumna; Moreira, Pedro; Perlas, Emerald; Heppenstall, Paul A.

doi:10.1186/1744-8069-7-66

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Generation and characterization of an Advillin-Cre driver mouse line

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Zurborg, S., Piszczek, A., Martinez, C., Hublitz, P., Al Banchaabouchi, M., Moreira, P., et al. (2011). Generation and characterization of an Advillin-Cre driver mouse line. Molecular Pain, 7: 66. doi:10.1186/1744-8069-7-66.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-1B51-9

Abstract

Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination in all peripheral sensory neurons. As such, the Advillin-Cre-driver line will be a powerful tool for targeting peripheral neurons in future investigations.