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Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin

MPG-Autoren
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Obermeier,  B.
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

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Mentele,  R.
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

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Wekerle,  H.
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

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Hohlfeld,  R.
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

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Dornmair,  K.
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

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Zitation

Obermeier, B., Lovato, L., Bruck, W., Forne, I., Imhof, A., Mentele, R., et al. (2011). Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Journal of Neuroimmunology, 233(1-2), 245-248.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0012-1EF0-B
Zusammenfassung
We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF. (C) 2011 Elsevier B.V. All rights reserved.