Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After 
Spinal Cord Injury

Hellal, F.; Hurtado, A.; Ruschel, J.; Flynn, K. C.; Laskowski, C. J.; Umlauf, M.; Kapitein, L. C.; Strikis, D.; Lemmon, V.; Bixby, J.; Hoogenraad, C. C.; Bradke, F.

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

MPS-Authors

/persons/resource/persons38885

Hellal, F.
Max Planck Research Group: Axonal Growth and Regeneration / Bradke, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons39045

Ruschel, J.
Max Planck Research Group: Axonal Growth and Regeneration / Bradke, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons38836

Flynn, K. C.
Max Planck Research Group: Axonal Growth and Regeneration / Bradke, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons38960

Laskowski, C. J.
Max Planck Research Group: Axonal Growth and Regeneration / Bradke, MPI of Neurobiology, Max Planck Society;

Umlauf, M.
Max Planck Society;

/persons/resource/persons38775

Bradke, F.
Max Planck Research Group: Axonal Growth and Regeneration / Bradke, MPI of Neurobiology, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Hellal, F., Hurtado, A., Ruschel, J., Flynn, K. C., Laskowski, C. J., Umlauf, M., et al. (2011). Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury. Science, 331(6019), 928-931.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-1F06-4

Abstract

Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. These processes are tightly regulated by microtubule dynamics. Here, moderate microtubule stabilization decreased scar formation after spinal cord injury in rodents through various cellular mechanisms, including dampening of transforming growth factor-beta signaling. It prevented accumulation of chondroitin sulfate proteoglycans and rendered the lesion site permissive for axon regeneration of growth-competent sensory neurons. Microtubule stabilization also promoted growth of central nervous system axons of the Raphe-spinal tract and led to functional improvement. Thus, microtubule stabilization reduces fibrotic scarring and enhances the capacity of axons to grow.