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Controlled Demolition: Smurf1 Regulates Neuronal Polarity by Substrate Switching

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Stiess,  M.
Max Planck Research Group: Axonal Growth and Regeneration / Bradke, MPI of Neurobiology, Max Planck Society;

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Bradke,  F.
Max Planck Research Group: Axonal Growth and Regeneration / Bradke, MPI of Neurobiology, Max Planck Society;

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Citation

Stiess, M., & Bradke, F. (2011). Controlled Demolition: Smurf1 Regulates Neuronal Polarity by Substrate Switching. Neuron, 69(2), 183-185.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-1F13-6
Abstract
During axon specification, growth promoting proteins localize selectively to the growing axon. In this issue of Neuron, Cheng et al. report how selective protein degradation, controlled by a substrate switch of the ubiquitin ligase Smurf1, specifies Par6 and RhoA localization and thereby regulates neuronal polarity.