English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Structural Long-Term Changes at Mushroom Body Input Synapses

MPS-Authors
/persons/resource/persons38944

Kremer,  M. C.
Research Group: Dendrite Differentiation / Tavosanis, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons38964

Leiss,  F.
Research Group: Dendrite Differentiation / Tavosanis, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons38930

Knapek,  S.
Research Group: Dendrite Differentiation / Tavosanis, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons38838

Förstner,  F.
Department: Systems and Computational Neurobiology / Borst, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons39095

Tavosanis,  G.
Research Group: Dendrite Differentiation / Tavosanis, MPI of Neurobiology, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Kremer, M. C., Christiansen, F., Leiss, F., Paehler, M., Knapek, S., Andlauer, T. F. M., et al. (2010). Structural Long-Term Changes at Mushroom Body Input Synapses. Current Biology, 20(21), 1938-1944.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-1F53-3
Abstract
How does the sensory environment shape circuit organization in higher brain centers? Here we have addressed the dependence on activity of a defined circuit within the mushroom body of adult Drosophila. This is a brain region receiving olfactory information and involved in long-term associative memory formation [1]. The main mushroom body input region, named the calyx, undergoes volumetric changes correlated with alterations of experience [2-5]. However, the underlying modifications at the cellular level remained unclear. Within the calyx, the clawed dendritic endings of mushroom body Kenyon cells form microglomeruli, distinct synaptic complexes with the presynaptic boutons of olfactory projection neurons [6, 7]. We developed tools for high-resolution imaging of pre- and postsynaptic compartments of defined calycal microglomeruli. Here we show that preventing firing of action potentials or synaptic transmission in a small, identified fraction of projection neurons causes alterations in the size, number, and active zone density of the microglomeruli formed by these neurons. These data provide clear evidence for activity-dependent organization of a circuit within the adult brain of the fly.