English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Fragile privileges: autoimmunity in brain and eye

MPS-Authors
/persons/resource/persons39114

Wekerle,  H.
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Wekerle, H., & Sun, D. M. (2010). Fragile privileges: autoimmunity in brain and eye. Acta Pharmacologica Sinica, 31(9), 1141-1148.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-1F74-A
Abstract
Brain and eye tissues are subject to a reduced version of immune surveillance, which has evolved to protect the particularly sensitive tissues from accidental bystander damage created by regular inflammatory responses. Yet, there are autoimmune diseases in both organs. This review discusses the nature of immune reactivity in the healthy eye and brain tissues, and mechanisms that can overcome the protective barriers to create tissue specific disease.