Fragile privileges: Autoimmunity in brain and eye

Wekerle, H.; Sun, D. M.

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Fragile privileges: Autoimmunity in brain and eye

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Wekerle, H.
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

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Wekerle, H., & Sun, D. M. (2010). Fragile privileges: Autoimmunity in brain and eye. Acta Pharmacologica Sinica, 31(9), 1141-1148.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-1F74-A

Abstract

Brain and eye tissues are subject to a reduced version of immune surveillance, which has evolved to protect the particularly sensitive tissues from accidental bystander damage created by regular inflammatory responses. Yet, there are autoimmune diseases in both organs. This review discusses the nature of immune reactivity in the healthy eye and brain tissues, and mechanisms that can overcome the protective barriers to create tissue specific disease.