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Journal Article

Signaling from Axon Guidance Receptors


Klein,  R.
Department: Molecular Neurobiology / Klein, MPI of Neurobiology, Max Planck Society;

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Bashaw, G. J., & Klein, R. (2010). Signaling from Axon Guidance Receptors. Cold Spring Harbor Perspectives in Biology, 2(5): a001941, pp. [1]-[16].

Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-1FC3-9
Determining how axon guidance receptors transmit signals to allow precise pathfinding decisions is fundamental to our understanding of nervous system development and may suggest new strategies to promote axon regeneration after injury or disease. Signaling mechanisms that act downstream of four prominent families of axon guidance cues-netrins, semaphorins, ephrins, and slits-have been extensively studied in both invertebrate and vertebrate model systems. Although details of these signaling mechanisms are still fragmentary and there appears to be considerable diversity in how different guidance receptors regulate the motility of the axonal growth cone, a number of common themes have emerged. Here, we review recent insights into how specific receptors for each of these guidance cues engage downstream regulators of the growth cone cytoskeleton to control axon guidance.