English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Cross-reactive T-Cell Receptors in Tumor and Paraneoplastic Target Tissue

MPS-Authors
/persons/resource/persons39106

Voltz,  R.
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons38855

Goebels,  N.
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons38897

Hohlfeld,  R.
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons38805

Dornmair,  K.
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Pellkofer, H. L., Voltz, R., Goebels, N., Hohlfeld, R., & Dornmair, K. (2009). Cross-reactive T-Cell Receptors in Tumor and Paraneoplastic Target Tissue. Archives of Neurology, 66(5), 655-658.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-2084-3
Abstract
Background: According to established criteria, paraneoplastic encephalomyelitis with adrenal neuroblastoma comprises a definite paraneoplastic neurologic syndrome. Objective: To detect T-cell clones that cross-react against antigens shared between tumor and nervous system. Design: Case study. Setting: Academic research. Patient: A 22-year-old woman having paraneoplastic encephalomyelitis with adrenal neuroblastoma. Main Outcome Measures: We compared the T-cell receptor repertoires expressed in blood, cerebrospinal fluid, and neuroblastoma tumor tissue using complementary determining region 3 (CDR3) spectratyping and clone-specific polymerase chain reaction. Results: The T-cell receptor repertoire in cerebrospinal fluid was narrow compared with that in tumor and blood. Four T-cell clones from different tissues had identical T-cell receptor beta chains. Remarkably, the chains showed identical amino acid sequences but different nucleotide sequences. Conclusions: These T cells represent ontogenetically distinct clones but share functionally identical receptors. They recognize the same antigen in nervous system and tumor tissue and represent an attractive target for selective therapy.