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Journal Article

EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion

MPS-Authors
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Zimmer,  M.
Department: Molecular Neurobiology / Klein, MPI of Neurobiology, Max Planck Society;

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Palmer,  A.
Research Group: Signal Transduction / Acker-Palmer, MPI of Neurobiology, Max Planck Society;

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Köhler,  J.
Department: Molecular Neurobiology / Klein, MPI of Neurobiology, Max Planck Society;

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Klein,  R.
Department: Molecular Neurobiology / Klein, MPI of Neurobiology, Max Planck Society;

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Citation

Zimmer, M., Palmer, A., Köhler, J., & Klein, R. (2003). EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nature Cell Biology, 5(10), 869-878.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-22FB-7
Abstract
Eph receptors and their membrane-associated ephrin ligands mediate cell-cell repulsion to guide migrating cells and axons. Repulsion requires that the ligand-receptor complex be removed from the cell surface, for example by proteolytic processing of the ephrin ectodomain. Here we show that cell contact-induced EphB-ephrinB complexes are rapidly endocytosed during the retraction of cells and neuronal growth cones. Endocytosis occurs in a bi-directional manner that comprises of full-length receptor and ligand complexes. Endocytosis is sufficient to promote cell detachment and seems necessary for axon withdrawal during growth cone collapse. Here, we show a mechanism for the termination of adhesion and the promotion of cell repulsion after intercellular (trans) interaction between two transmembrane proteins.