English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Met signaling is required for recruitment of motor neurons to PEA3-positive motor pools

MPS-Authors
/persons/resource/persons38886

Helmbacher,  Francoise
Department: Molecular Neurobiology / Klein, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons38927

Klein,  Rüdiger
Department: Molecular Neurobiology / Klein, MPI of Neurobiology, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Helmbacher, F., Dessaud, E., Arber, S., deLapeyriere, O., Henderson, C., Klein, R., et al. (2003). Met signaling is required for recruitment of motor neurons to PEA3-positive motor pools. Neuron, 39(5), 767-777.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-2309-0
Abstract
Motor neurons in the spinal cord are grouped into motor pools, each of which innervates a single muscle. The ETS transcription factor PEA3 is a marker of a few such motor pools. Here, we show that pea3 is first induced by GDNF in a caudal subset of the motor neurons that will constitute the pea3+ population. Expansion of the pea3 domain subsequently occurs by recruitment of neurons from more anterior segments. Signaling by Met, the HGF receptor, is required for the rostral expansion of the pea3 domain, while the onset of pea3 expression is independent of met function. met expression is observed in pioneer neurons but does not precede that of pea3 in recruited neurons. We provide genetic evidence for a non-cell-autonomous function of met during the recruitment process. We propose the presence of a relay mechanism allowing cells induced by peripheral signals to recruit more anterior neurons to adopt the same motor pool-related phenotype.