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Selective unresponsiveness to conformational B cell epitopes of the myelin oligodendrocyte glycoprotein in H-2(b) mice

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Bourquin,  Carole
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

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Schubart,  Anna
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

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Linington,  Christopher
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

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Citation

Bourquin, C., Schubart, A., Tobollik, S., Mather, I., Ogg, S., Liblau, R., et al. (2003). Selective unresponsiveness to conformational B cell epitopes of the myelin oligodendrocyte glycoprotein in H-2(b) mice. Journal of Immunology, 171(1), 455-461.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-2311-D
Abstract
Autoantibodies directed against conformation-dependent epitopes of the extracellular domain of the myelin oligodendrocyte glycoprotein (MOG(Igd)) play a major role in the immunopathogenesis of demyelination in experimental autoimmune encephalomyelitis. We now demonstrate that one or more genes encoded within the MHC selectively censor the ability of H-2(b) mice to mount this conformation-dependent autoantibody response, while leaving T and B cell responses to linear MOG(Igd) epitopes intact. This novel form of selective B cell unresponsiveness discriminates between pathogenic and nonpathogenic Ab responses to MOG and determines whether or not Ab-dependent effector mechanisms play an important role in the pathogenesis of MOG-induced experimental autoimmune encephalomyelitis in the mouse.