Neurotrophins: From enthusiastic expectations through sobering experiences to 
rational therapeutic approaches

Thoenen, H.; Sendtner, M.

doi:10.1038/nn938

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Neurotrophins: From enthusiastic expectations through sobering experiences to rational therapeutic approaches

MPS-Authors

/persons/resource/persons39097

Thoenen, H.
Emeritus Group: Neurochemistry / Thoenen, MPI of Neurobiology, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Thoenen, H., & Sendtner, M. (2002). Neurotrophins: From enthusiastic expectations through sobering experiences to rational therapeutic approaches. Nature Neuroscience, 5(11, Suppl.), 1046-1050. doi:10.1038/nn938.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-2350-0

Abstract

Despite high enthusiasm, early attempts to develop clinical treatments based on animal research with neurotrophins were not successful. Here we survey clinical trials with neurotrophins, compared with neurotrophic factors of other gene families, and delineate the most likely reasons for their failure. We then suggest improved methods for regulated local supply of NTs to specific populations of neurons and discuss future therapeutic procedures evolving from the more detailed knowledge of the signal transduction pathways activated by neurotrophins via their receptors.