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Journal Article

The neurotrophin receptor p75(NTR): Novel functions and implications for diseases of the nervous system

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Dechant,  Georg
Department: Neurobiochemie / Barde, MPI of Neurobiology, Max Planck Society;

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Citation

Dechant, G., & Barde, Y. A. (2002). The neurotrophin receptor p75(NTR): Novel functions and implications for diseases of the nervous system. Nature Neuroscience, 5(11), 1131-1136. doi:10.1038/nn1102-1131.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-2351-E
Abstract
Neurotrophins have long been known to promote the survival and differentiation of vertebrate neurons. However, these growth factors can also induce cell death through the p75 neurotrophin receptor (p75(NTR)), a member of the tumor necrosis factor receptor superfamily. Consistent with a function in controlling the survival and process formation of neurons, p75(NTR) is mainly expressed during early neuronal development. In the adult, p75(NTR) is re-expressed in various pathological conditions, including epilepsy, axotomy and neurodegeneration. Potentially toxic peptides, including the amyloid beta- (Abeta- ) peptide that accumulates in Alzheimer's disease, are ligands for p75(NTR). Recent work also implicates p75(NTR) in the regulation of both synaptic transmission and axonal elongation. It associates with the Nogo receptor, a binding protein for axonal growth inhibitors, and appears to be the transducing subunit of this receptor complex.