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Journal Article

Mechanism of TrkB-mediated hippocampal long-term potentiation

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Bonhoeffer,  Tobias
Department: Cellular and Systems Neurobiology / Bonhoeffer, MPI of Neurobiology, Max Planck Society;

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Klein,  Rüdiger
Department: Molecular Neurobiology / Klein, MPI of Neurobiology, Max Planck Society;

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Korte,  Martin
Department: Cellular and Systems Neurobiology / Bonhoeffer, MPI of Neurobiology, Max Planck Society;

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Citation

Minichiello, L., Calella, A., Medina, D., Bonhoeffer, T., Klein, R., & Korte, M. (2002). Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron, 36(1), 121-137. doi:10.1016/S0896-6273(02)00942-X.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-2356-4
Abstract
The TrkB receptor tyrosine kinase and its ligand, BDNF, have an essential role in certain forms of synaptic plasticity. However, the downstream pathways required to mediate these functions are unknown. We have studied mice with a targeted mutation in either the Shc or the phospholipase Cgamma (PLCgamma) docking sites of TrkB (trkB(SHC/SHC) and trkB(PLC/PLC) mice). We found that hippocampal long-term potentiation was impaired in trkB(PLC/PLC) mice, but not trkB(SHC/SHC) mice. BDNF stimulation of primary neurons derived from trkB(PLC/PLC) mice fully retained their ability to activate MAP kinases, whereas induction of CREB and CaMKIV phosphorylation was strongly impaired. The opposite effect was observed in trkB(SHC/SHC) neurons, suggesting that MAPKs and CREB act in parallel pathways. Our results provide genetic evidence that TrkB mediates hippocampal plasticity via recruitment of PLCgamma, and by subsequent phosphorylation of CaMKIV and CREB.