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Journal Article

Chat in the trophic web: NGF activates Ret by inter-RTK signaling

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Dechant,  Georg
Department: Neurobiochemie / Barde, MPI of Neurobiology, Max Planck Society;

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Citation

Dechant, G. (2002). Chat in the trophic web: NGF activates Ret by inter-RTK signaling. Neuron, 33(2), 156-158. doi:10.1016/S0896-6273(02)00564-0.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-2389-1
Abstract
In this issue of Neuron, Tsui-Pierchala et al. (2002) show that in rodent SCG neurons NGF activates Ret, the signaling component of the multisubunit GDNF receptor, in vitro and in vivo by a mechanism, which is independent of GFL ligands and GFRalpha coreceptors. NGF-dependent Ret phosphorylation regulates soma size and metabolism but not survival of maturing postnatal sympathetic neurons.