An implantable RF solenoid for magnetic resonance microscopy and 
microspectroscopy

Rivera, Deborah; Cohen, Mark; Clark, W. G.; Chu, Allen; Nunnally, Ray; Smith, Jolinda; Mills, Dixie; Judy, Jack

doi:10.1109/TBME.2011.2178239

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An implantable RF solenoid for magnetic resonance microscopy and microspectroscopy

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Rivera, Deborah
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Rivera, D., Cohen, M., Clark, W. G., Chu, A., Nunnally, R., Smith, J., et al. (2012). An implantable RF solenoid for magnetic resonance microscopy and microspectroscopy. IEEE Transactions on Biomedical Engineering, 59(8), 2118-2125. doi:10.1109/TBME.2011.2178239.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-33B2-2

Abstract

Miniature solenoids routinely enhance small volume nuclear magnetic resonance imaging and spectroscopy; however, no such techniques exist for patients. We present an implantable microcoil for diverse clinical applications, with a microliter coil volume. The design is loosely based on implantable depth electrodes, in which a flexible tube serves as the substrate, and a metal stylet is inserted into the tube during implantation. The goal is to provide enhanced signal-to-noise ratio (SNR) of structures that are not easily accessed by surface coils. The first-generation prototype was designed for implantation up to 2 cm, and provided initial proof-of-concept for microscopy. Subsequently, we optimized the design to minimize the influence of lead inductances, and to thereby double the length of the implantable depth (4 cm). The second-generation design represents an estimated SNR improvement of over 30% as compared to the original design when extended to 4 cm. Impedance measurements indicate that the device is stable for up to 24 h in body temperature saline. We evaluated the SNR and MR-related heating of the device at 3T. The implantable microcoil can differentiate fat and water peaks, and resolve submillimeter features.