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Journal Article

An implantable RF solenoid for magnetic resonance microscopy and microspectroscopy


Rivera,  Deborah
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Rivera, D., Cohen, M., Clark, W. G., Chu, A., Nunnally, R., Smith, J., et al. (2012). An implantable RF solenoid for magnetic resonance microscopy and microspectroscopy. IEEE Transactions on Biomedical Engineering, 59(8), 2118-2125. doi:10.1109/TBME.2011.2178239.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-33B2-2
Miniature solenoids routinely enhance small volume nuclear magnetic resonance imaging and spectroscopy; however, no such techniques exist for patients. We present an implantable microcoil for diverse clinical applications, with a microliter coil volume. The design is loosely based on implantable depth electrodes, in which a flexible tube serves as the substrate, and a metal stylet is inserted into the tube during implantation. The goal is to provide enhanced signal-to-noise ratio (SNR) of structures that are not easily accessed by surface coils. The first-generation prototype was designed for implantation up to 2 cm, and provided initial proof-of-concept for microscopy. Subsequently, we optimized the design to minimize the influence of lead inductances, and to thereby double the length of the implantable depth (4 cm). The second-generation design represents an estimated SNR improvement of over 30% as compared to the original design when extended to 4 cm. Impedance measurements indicate that the device is stable for up to 24 h in body temperature saline. We evaluated the SNR and MR-related heating of the device at 3T. The implantable microcoil can differentiate fat and water peaks, and resolve submillimeter features.