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Functional conservation of wheat and rice Mlo orthologs in defense modulation to the powdery mildew fungus

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Panstruga,  R.
Dept. of Plant Microbe Interactions (Paul Schulze-Lefert), MPI for Plant Breeding Research, Max Planck Society;

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Schulze-Lefert,  P.
Dept. of Plant Microbe Interactions (Paul Schulze-Lefert), MPI for Plant Breeding Research, Max Planck Society;

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Citation

Elliott, C., Zhou, F. S., Spielmeyer, W., Panstruga, R., & Schulze-Lefert, P. (2002). Functional conservation of wheat and rice Mlo orthologs in defense modulation to the powdery mildew fungus. Molecular Plant-Microbe Interactions, 15(10), 1069-1077.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-3D73-4
Abstract
Homologs of barley Mlo are found in syntenic positions in all three genomes of hexaploid bread wheat, Triticum aestivum, and in rice, Oryza sativa. Candidate wheat orthologs, designated TaMlo-A1, TaMlo-B1, and TaMlo-D1, encode three distinct but highly related proteins that are 88% identical to barley MLO and appear to originate from the three diploid ancestral genomes of wheat. TaMlo-B1 and the rice ortholog, OsMlo2, are able to complement powdery mildew-resistant barley mlo mutants at the single-cell level. Overexpression of TaMlo-B1 or barley Mlo leads to super-susceptibility to the appropriate powdery mildew formae speciales in both wild-type barley and wheat. Surprisingly, overexpression of either Mlo or TaMlo-B1 also mediates enhanced fungal development to tested inappropriate formae speciales. These results underline a regulatory role for MLO and its wheat and rice orthologs in a basal defense mechanism that can interfere with forma specialis resistance to powdery mildews.