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Journal Article

The RAR1 interactor SGT1, an essential component of R gene- triggered disease resistance

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Freialdenhoven,  A.
Dept. of Plant Microbe Interactions (Paul Schulze-Lefert), MPI for Plant Breeding Research, Max Planck Society;

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Schulze-Lefert,  P.
Dept. of Plant Microbe Interactions (Paul Schulze-Lefert), MPI for Plant Breeding Research, Max Planck Society;

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Citation

Azevedo, C., Sadanandom, A., Kitagawa, K., Freialdenhoven, A., Shirasu, K., & Schulze-Lefert, P. (2002). The RAR1 interactor SGT1, an essential component of R gene- triggered disease resistance. Science, 295(5562), 2073-2076.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-3DF9-9
Abstract
Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence: point in a signaling pathway engaged by multiple R genes. Here, vie show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene- triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.