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Journal Article

Cortico-subthalamic white matter tract strength predict interindividual efficacy in stopping a motor response

MPS-Authors
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Bazin,  Pierre-Louis
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Neumann,  Jane
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;

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Schäfer,  Andreas
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Anwander,  Alfred
Methods and Development Unit Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Turner,  Robert
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Forstmann, B. U., Keuken, M. C., Jahfari, S., Bazin, P.-L., Neumann, J., Schäfer, A., et al. (2012). Cortico-subthalamic white matter tract strength predict interindividual efficacy in stopping a motor response. NeuroImage, 60(1), 370-375. doi:10.1016/j.neuroimage.2011.12.044.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-61E6-1
Abstract
The subthalamic nucleus (STN) is a small but vitally important structure in the basal ganglia. Because of its small volume, and its localization in the basal ganglia, the STN can best be visualized using ultra-high resolution 7 Tesla (T) magnetic resonance imaging (MRI). In the present study, first we individually segmented 7T MRI STN masks to generate atlas probability maps. Secondly, the individually segmented STN masks and the probability maps were used to derive cortico-subthalamic white matter tract strength. Tract strength measures were then taken to test two functional STN hypotheses which account for the efficiency in stopping a motor response: the right inferior fronto-subthalamic (rIFC-STN) hypothesis and the posterior medial frontal cortex-subthalamic (pMFC-STN) hypothesis. Results of two independent experiments show that increased white matter tract strength between the pMFC and STN results in better stopping behaviour.