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Journal Article

The dynamic structure of filamentous tau.

MPS-Authors
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Bibow,  S.
Research Group of Protein Structure Determination using NMR, MPI for biophysical chemistry, Max Planck Society;

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Griesinger,  C.
Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society;

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Zweckstetter,  M.
Research Group of Protein Structure Determination using NMR, MPI for biophysical chemistry, Max Planck Society;

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Citation

Bibow, S., Mukrasch, M. D., Chinnathambi, S., Biernat, J., Griesinger, C., Mandelkow, E., et al. (2011). The dynamic structure of filamentous tau. Angewandte Chemie-International Edition, 50(48), 11520-11524. doi:0.1002/anie.20110549.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-13F2-8
Abstract
Getting inside a fuzzy coat: The dynamic structure of the “fuzzy coat”, N- and C-terminal sections around the core of the tau filament consists of over 200 amino acids, and has been characterized by NMR spectroscopy (see picture, model of the long range interactions). The results indicate how conformation specific antibodies bind to the tau protein (fibers of which are a characteristic symptom of Alzheimer disease).