Deutsch
 
Benutzerhandbuch Datenschutzhinweis Impressum Kontakt
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Single-protein force spectroscopy: Sequence dependence

MPG-Autoren
/persons/resource/persons48276

Lee,  N.
MPI for Polymer Research, Max Planck Society;

/persons/resource/persons48919

Vilgis,  Thomas A.
MPI for Polymer Research, Max Planck Society;

Externe Ressourcen
Es sind keine Externen Ressourcen verfügbar
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Lee, N., & Vilgis, T. A. (2002). Single-protein force spectroscopy: Sequence dependence. Europhysics Letters, 57(6), 817-823.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-000F-667B-4
Zusammenfassung
We study the elastic properties of a single A/B copolymer chain with a specific sequence. We predict a rich structure in the force-extension relations which can be addressed to the sequence. The variational method is introduced to probe local minima on the path of stretching and releasing. At a given force, we find multiple configurations which are separated by energy barriers. A collapsed globular configuration consists of several domains which unravel cooperatively. Upon stretching, the unfolding path shows a stepwise pattern corresponding to the unfolding of each domain. While releasing, several cores can be created simultaneously in the middle of the chain resulting in a different path of collapse.