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Psoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay.

MPS-Authors
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Samatov,  T. R.
Department of Cellular Biochemistry, MPI for biophysical chemistry, Max Planck Society;

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Odenwälder,  P.
Department of Cellular Biochemistry, MPI for biophysical chemistry, Max Planck Society;

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Bessonov,  S.
Department of Cellular Biochemistry, MPI for biophysical chemistry, Max Planck Society;

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Lührmann,  R.
Department of Cellular Biochemistry, MPI for biophysical chemistry, Max Planck Society;

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Supplementary Material (public)

1443672_Supplement.pdf
(Supplementary material), 315KB

Citation

Samatov, T. R., Wolf, A., Odenwälder, P., Bessonov, S., Deraeve, C., Bon, R. S., et al. (2012). Psoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay. ChemBioChem, 13(5), 640-644. doi:10.1002/cbic.201100790.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-83A1-4
Abstract
Snapshots of spliceosome assembly: A high-throughput in vitro splicing assay has been developed for screening a compound library. The discovered family of pre-mRNA splicing inhibitors comprises lichen secondary metabolites that allow the enrichment of the spliceosomal complexes formed after the spliceosome activation step. Here we identify the structural features important for the compounds' inhibitory activity.