Direct Catalytic Asymmetric Three-Component Kabachnik-Fields Reaction

Cheng, Xu; Goddard, Richard; Buth, Gernot; List, Benjamin

doi:10.1002/anie.200801173

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Direct Catalytic Asymmetric Three-Component Kabachnik-Fields Reaction

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Cheng, Xu
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Goddard, Richard
Service Department Lehmann (EMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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List, Benjamin
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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引用

Cheng, X., Goddard, R., Buth, G., & List, B. (2008). Direct Catalytic Asymmetric Three-Component Kabachnik-Fields Reaction. Angewandte Chemie International Edition, 47(27), 5079-5081. doi:10.1002/anie.200801173.

引用: https://hdl.handle.net/11858/00-001M-0000-000F-8FF1-0

要旨

As mimics of α‐amino acids, α‐amino phosphonates have great promise as antibacterial and anti‐HIV agents as well as protease inhibitors. Racemic α‐branched aldehydes react, in the presence the new chiral phosphoric acid catalyst 1, directly with p‐anisidine (PMPNH₂) and a phosphite to furnish β‐branched α‐amino phosphonates highly diastereoselectively and enantioselectively.