Chiral Counteranions in Asymmetric Transition-Metal Catalysis: Highly 
Enantioselective Pd/Brønsted Acid-Catalyzed Direct α-Allylation of Aldehydes

Mukherjee, Santanu; List, Benjamin

doi:10.1021/ja074678r

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Chiral Counteranions in Asymmetric Transition-Metal Catalysis: Highly Enantioselective Pd/Brønsted Acid-Catalyzed Direct α-Allylation of Aldehydes

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Mukherjee, Santanu
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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List, Benjamin
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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引用

Mukherjee, S., & List, B. (2007). Chiral Counteranions in Asymmetric Transition-Metal Catalysis: Highly Enantioselective Pd/Brønsted Acid-Catalyzed Direct α-Allylation of Aldehydes. Journal of the American Chemical Society, 129(37), 11336-11337. doi:10.1021/ja074678r.

引用: https://hdl.handle.net/11858/00-001M-0000-000F-913F-6

要旨

We have developed a highly enantioselective Pd/chiral acid-catalyzed α-allylation of α-branched aldehydes with an allyl amine as the allylating species that creates all-carbon quaternary stereogenic centers in high yields and enantioselectivities. To our knowledge, this is the first time that a chiral anionic ligand is applied for achieving asymmetric induction in a palladium-catalyzed allylic alkylation reaction.