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Concise and Practical Synthesis of Latrunculin A by Ring-Closing Enyne-Yne Metathesis

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Fürstner,  Alois
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Turet,  Laurent
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Fürstner, A., & Turet, L. (2005). Concise and Practical Synthesis of Latrunculin A by Ring-Closing Enyne-Yne Metathesis. Angewandte Chemie International Edition, 44(22), 3462-3466. doi:10.1002/anie.200500390.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-94E3-3
Abstract
Selective actin-binding is the most prominent biochemical property of the scarce marine natural product latrunculin A (see formula). Modern metal-catalyzed C-C bond-formation reactions, including a ring-closing enyne–yne metathesis (shown in red), now open a convenient, flexible, and productive entry to this important probe molecule for chemical biology.