English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Study towards bioactive pyrone derivatives from the marine red alga Phacelocarpus labillardieri

MPS-Authors
/persons/resource/persons59004

Song,  Dschun
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons58433

Blond,  Gaëlle
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons58380

Fürstner,  Alois
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Song, D., Blond, G., & Fürstner, A. (2003). Study towards bioactive pyrone derivatives from the marine red alga Phacelocarpus labillardieri. Tetrahedron, 59(35), 6899-6904. doi:10.1016/S0040-4020(03)00815-9.


Cite as: https://hdl.handle.net/11858/00-001M-0000-000F-983D-E
Abstract
Red algae of the genus Phacelocarpus labillardieri produce a structurally rather unique class of macrocyclic pyrone derivatives with phospholipase A2 inhibiting properties and potential neuromuscular blocking activity. They were also shown to be potent feeding inhibitors for various marine herbivorous gastropods. Described herein is the first preparative study towards these conspicuous secondary metabolites. Their carbon skeleton has been assembled in a few straightforward steps using ring closing alkyne metathesis (RCAM) catalyzed by the Schrock alkylidyne complex (tBuO)3WC≡CMe3 to forge the meta-cyclophane core with high efficiency.