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A practical NMR-based high-throughput assay for screening enantioselective catalysts and biocatalysts

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Reetz,  M. T.
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons58529

Eipper,  A.
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons59049

Tielmann,  P.
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Mynott,  R.
Service Department Mynott (NMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Service Department Mynott (NMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Service Department Mynott (NMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Reetz, M. T., Eipper, A., Tielmann, P., & Mynott, R. (2002). A practical NMR-based high-throughput assay for screening enantioselective catalysts and biocatalysts. Advanced Synthesis & Catalysis, 344(9), 1008-1016. doi:10.1002/1615-4169(200210)344:9<1008:AID-ADSC1008>3.0.CO;2-T.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-9989-7
Abstract
Two NMR-based approaches for high-throughput screening of enantioselective catalysts and biocatalysts are described. One version makes use of pseudo-enantiomers or pseudo-meso- compounds based on C-13-labeling. A throughput of at least 1400 ee determinations per day is possible by using an appropriate flow-through cell and an autosampler. The other approach is based on traditional diastereomer formation using a chiral reagent or complexing agent. The ee values are accurate to within +/-2% and +/-5% of the true values.