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Journal Article

How SNARE molecules mediate membrane fusion: Recent insights from molecular simulations.

MPS-Authors
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Risselada,  H. J.
Department of Theoretical and Computational Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Grubmuller,  H.
Department of Theoretical and Computational Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Citation

Risselada, H. J., & Grubmuller, H. (2012). How SNARE molecules mediate membrane fusion: Recent insights from molecular simulations. Current Opinion in Structural Biology, 22(2), 187-196. doi:10.1016/j.sbi.2012.01.007.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-9AF2-4
Abstract
SNARE molecules are the core constituents of the protein machinery that facilitate fusion of synaptic vesicles with the presynaptic plasma membrane, resulting in the release of neurotransmitter. On a molecular level, SNARE complexes seem to play a quite versatile and involved role during all stages of fusion. In addition to merely triggering fusion by forcing the opposing membranes into close proximity, SNARE complexes are now seen to also overcome subsequent fusion barriers and to actively guide the fusion reaction up to the expansion of the fusion pore. Here, we review recent advances in the understanding of SNARE-mediated membrane fusion by molecular simulations.