The potential of microvessel density in prediction of infarct growth: A 
two-month experimental study in vessel size imaging

Xu, Chao; Schmidt, Wolf U.H.; Galinovic, Ivana; Villringer, Kersten; Hotter, Benjamin; Ostwaldt, Ann-Christin; Denisova, Natalia; Kellner, Elias; Kiselev, Valerij; Fiebach, Jochen B.

doi:10.1159/000335302

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The potential of microvessel density in prediction of infarct growth: A two-month experimental study in vessel size imaging

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Xu, C., Schmidt, W. U., Galinovic, I., Villringer, K., Hotter, B., Ostwaldt, A.-C., et al. (2012). The potential of microvessel density in prediction of infarct growth: A two-month experimental study in vessel size imaging. Cerebrovascular Diseases, 33(4), 303-309. doi:10.1159/000335302.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000F-A3B4-5

Abstract

Objectives: Vessel size imaging is a novel technique to evaluate pathological changes of the microvessel density quantity Q and the mean vessel size index (VSI). As a follow-up study, we assessed these parameters for microscopic description of ischemic penumbra and their potentials in predicting lesion growth. Methods: Seventy-five patients with a perfusion-diffusion mismatch were examined within 24 h from symptom onset. We defined three regions of interest: the initial infarct (INF), the ischemic penumbra (IPE), and the healthy region (HEA) symmetric to the IPE. For 23 patients with a 6th-day follow-up, IPE regions were divided into areas of infarct growth and areas of oligemia. Result: The median values of Q and VSI were: for INF 0.29 s-1/3 and 15.8 µm, for IPE 0.33 s-1/3 and 20.6 µm and for HEA 0.36 s-1/3 and 17.4 µm. The Q in the IPE was significantly smaller than in HEA, and VSI was significantly larger. The Q with a threshold of 0.32 s-1/3 predicted the final infarction with a sensitivity of 69% and a specificity of 64%. Conclusions: The reduced Q and increased VSI in the IPE confirmed our previous pilot results. Although Q showed a trend to identify the severity of ischemia in an overall voxel population, its potential in predicting infarct growth needs to be further tested in a larger cohort including a clear status of reperfusion and recanalization.