New drug for inhibiting aggregation of proteins involved in diseases linked to 
protein aggregation and/or neurodegenerative diseases.

Giese, A.; Bertsch, U.; Kretzschmar, H.; Habeck, M.; Hirschberger, T.; Tavan, P.; Griesinger, C.; Leonov, A.; Ryazanov, S.; Weber, P.

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特許

New drug for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases.

MPS-Authors

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Griesinger, C.
Department of NMR-Based Structural Biology, MPI for biophysical chemistry, Max Planck Society;

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Leonov, A.
Department of NMR-Based Structural Biology, MPI for biophysical chemistry, Max Planck Society;

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Ryazanov, S.
Department of NMR-Based Structural Biology, MPI for biophysical chemistry, Max Planck Society;

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引用

Giese, A., Bertsch, U., Kretzschmar, H., Habeck, M., Hirschberger, T., Tavan, P., Griesinger, C., Leonov, A., Ryazanov, S., & Weber, P.(2010). New drug for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases.

引用: https://hdl.handle.net/11858/00-001M-0000-000F-D1F6-C

要旨

The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed. Formula (E) wherein X, Y and L are independently nondirectionally selected from -C(R1)(R2)-, -C(R3)=, -N(R4)-, -N=, -N+(R5)=, -O- and -S-; M and Z are independently nondirectionally selected from formula (I) and formula (II).