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Center-out echo-planar spectroscopic imaging with correction of gradient-echo phase and time shifts

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Labadie,  Christian
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Laboratoire de Spectrométrie Ionique et Moléculaire, Université Claude Bernard, Lyon, France;
Faculty of Physics and Earth Sciences, University of Leipzig, Germany;

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Schulz,  Jessica
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Mildner,  Toralf
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Möller,  Harald E.
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Faculty of Physics and Earth Sciences, University of Leipzig, Germany;

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Citation

Labadie, C., Hetzer, S., Schulz, J., Mildner, T., Aubert-Frécon, M., & Möller, H. E. (2013). Center-out echo-planar spectroscopic imaging with correction of gradient-echo phase and time shifts. Magnetic Resonance in Medicine, 70(1), 16-24. doi:10.1002/mrm.24428.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-D22C-C
Abstract
A procedure to prevent the formation of image and spectral Nyquist ghosts in echo-planar spectroscopic imaging is introduced. It is based on a novel Cartesian center-out echo-planar spectroscopic imaging trajectory, referred to as EPSICO, and combined with a correction of the gradient-echo phase and time shifts. Processing of homogenous sets of forward and reflected echoes is no longer necessary, resulting in an optimized spectral width. The proposed center-out trajectory passively prevents the formation of Nyquist ghosts by privileging the acquisition of the center k-space line with forward echoes at the beginning of an echo-planar spectroscopic imaging dwell time and by ensuring that all k-space lines and their respective complex conjugates are acquired at equal time intervals. With the proposed procedure, concentrations of N-acetyl aspartate, creatine, choline, glutamate, and myo-inositol were reliably determined in human white matter at 3 T.