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Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity.

MPS-Authors
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Kalbe,  Martin
Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Eizaguirre,  Christophe
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Reusch,  Thorsten B. H.
Department Ecophysiology, Max Planck Institute for Limnology, Max Planck Institute for Evolutionary Biology, Max Planck Society;
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Sommerfeld,  Ralf D.
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Wegner,  K. Mathias
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Milinski,  Manfred
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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kalbe09encl.pdf
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Citation

Kalbe, M., Eizaguirre, C., Dankert, I., Reusch, T. B. H., Sommerfeld, R. D., Wegner, K. M., et al. (2009). Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity. Proceedings of the Royal Society of London, Series B, 276(1658), 925-934. doi:10.1098/rspb.2008.1466.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-D5E2-9
Abstract
Individual diversity at the major histocompatibility complex (MHC) is predicted to be optimal at intermediate rather than at maximal levels. We showed previously in sticklebacks that an intermediate MHC diversity is predominant in natural populations and provides maximal resistance in experimental multiple parasite infections in the laboratory. However, what counts ultimately is the lifetime reproductive success (LRS). Here, we measured LRS of six laboratory-bred sib-groups-to minimize the influence of non-MHC genes-three-spined sticklebacks (Gasterosteus aculeatus) during their entire breeding period, each in a seminatural enclosure in the lake of their parents, where they were exposed to the natural spectrum of parasites. We collected developing clutches at regular intervals and determined parenthood for a representative number of eggs (2279 in total) per clutch with 18 microsatellites. Both males and females with an intermediate MHC class IIB variant number had the highest LRS. The mechanistic link of MHC diversity and LRS differed between the sexes: in females, we found evidence for a trade-off between number of eggs and immunocompentence, whereas in males this correlation was concealed by different timing strategies of reproduction.