A segmentation gene in Tribolium produces a polycistronic mRNA that codes for 
multiple conserved peptides

Savard, Joel; Marques-Souza, Henrique; Aranda, Manuel; Tautz, Diethard

doi:10.1016/j.cell.2006.05.053

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

リリース履歴を表示詳細要約

公開

学術論文

A segmentation gene in Tribolium produces a polycistronic mRNA that codes for multiple conserved peptides

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Savard, J., Marques-Souza, H., Aranda, M., & Tautz, D. (2006). A segmentation gene in Tribolium produces a polycistronic mRNA that codes for multiple conserved peptides. Cell, 126(3), 559-569. doi:10.1016/j.cell.2006.05.053.

引用: https://hdl.handle.net/11858/00-001M-0000-0010-0E23-5

要旨

Segmentation genes in insects are required for generating the subdivisions of the early embryo. We describe here a new member of the gap family of segmentation genes in the flour beetle Tribolium, mille-pattes (mlpt). mlpt knockdown leads to transformation of the abdominal segments into thoracic segments, providing embryos with up to ten pairs of legs. We show that there are crossregulatory interactions between mlpt and the known gap genes in Tribolium, suggesting that mlpt is itself a gap gene. The mlpt gene reveals an unusual structure, as it encodes a polycistronic mRNA that codes for four peptides. mlpt appears to be the prototype of this previously unknown gene structure in eukaryotes, as we find homologous genes with the same polycistronic arrangement in other insect genomes; as well.