Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

A Hox class 3 orthologue from the spider Cupiennius salei is expressed in a Hox-gene like fashion

There are no MPG-Authors in the publication available
External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Damen, W. G. M., & Tautz, D. (1998). A Hox class 3 orthologue from the spider Cupiennius salei is expressed in a Hox-gene like fashion. Development Genes and Evolution, 208(10), 586-590. doi:10.1007/s004270050218.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-0EB3-0
The class 3 Hox gene orthologue in insects, zerknullt (zen), is not expressed along the anterior-posterior axis, but only in extra-embryonic tissues, suggesting that it has lost its function as a normal Hox gene. To analyse whether this loss of Hox gene function has already occurred in a basal arthropod lineage, we have isolated a Hox3 orthologue from the spider Cupiennius salei. In contrast to the insect ten sequences, which have a highly diverged homeobox, the spider Hox3 gene orthologue, Cs-Hox3, shows a high sequence similarity to the class 3 Hox genes of other phyla, including chordates. In situ hybridization in early embryos shows that it is expressed in a continuous region covering the pedipalp segment and the four leg-bearing segments. This expression pattern suggests a Hox-gene-like function for Cs-Hox3. On the other hand, the expression pattern does not strictly follow the colinearity rule, as it overlaps fully with the expression domain of the class 1 orthologue of the spider, Cs-lab. Still, our data suggest that the ancestor of the arthropods must have had a class 3 Hox gene with a function in anterior-posterior axis specification and that this function has been lost in the lineage leading to the insects.